產(chǎn)品詳情介紹
纖維連接蛋白（Fibronectin，F(xiàn)N），又稱纖粘蛋白，能促進(jìn)細(xì)胞的黏連生長，而細(xì)胞的黏連是機體結(jié)構(gòu)得以維持、細(xì)胞生長完成的必要條件。因此，F(xiàn)N是細(xì)胞培養(yǎng)基的重要成分之一。此外FN能提高細(xì)胞的融合率，縮短融合周期[1-3]。血漿纖維連接蛋白由肝細(xì)胞分泌，并結(jié)合到細(xì)胞表面，轉(zhuǎn)變?yōu)檠由鞓?gòu)象并組裝成纖維連接蛋白纖維[4]。另外，由于FN的EDA和EDB結(jié)構(gòu)域在腫瘤血管中特異性表達(dá)，它們被廣泛用于靶向遞送細(xì)胞因子、細(xì)胞毒素、化療藥物和放射性同位素，以對原發(fā)癌和轉(zhuǎn)移病變產(chǎn)生治療效果[5]。
[1] Kelsh-Lasher RM, Ambesi A, Bertram C, McKeown-Longo PJ. Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain. J Invest Dermatol. 2017, 137(12):2505-2512.
[2] Amin A, Chikan NA, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016, 6:37151.
[3] Dhanesha N, Ahmad A, Prakash P, Doddapattar P, Lentz SR, Chauhan AK. Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation. Circulation. 2015, 132(23):2237-2247.
[4] Maurer LM, Ma W, Mosher DF. Dynamic structure of plasma fibronectin. Crit Rev Biochem Mol Biol. 2015, 51(4):213-227.
[5] Kumra H, Reinhardt DP. Fibronectin-targeted drug delivery in cancer. Adv Drug Deliv Rev. 2016, 97:101-110.
