產(chǎn)品詳情介紹
Activin A由兩個(gè)抑制素β亞基通過(guò)二硫鍵連接組成同型二聚體，通過(guò)特定的受體激活細(xì)胞內(nèi)的信號(hào)傳導(dǎo)途徑。Activin A在調(diào)控細(xì)胞的生長(zhǎng)、分化、凋亡以及組織修復(fù)等多種生物學(xué)過(guò)程中起著關(guān)鍵作用[1]。Activin A通過(guò)與I型和II型激活素受體結(jié)合，激活SMAD依賴性信號(hào)通路，從而調(diào)節(jié)目標(biāo)基因的表達(dá)。這一過(guò)程對(duì)于多種細(xì)胞功能和發(fā)育過(guò)程至關(guān)重要[2-3]。Activin A參與了多種疾病的發(fā)病機(jī)制，包括某些癌癥的發(fā)展、自身免疫性疾病的病理過(guò)程以及組織纖維等。Activin A的調(diào)節(jié)作用使其成為治療策略中的潛在靶點(diǎn)，尤其是在促進(jìn)傷口愈合、改善免疫功能以及抗癌治療中 [4-6]。
[1] Massague J, Blain SW, Lo RS. TGFβ signaling in growth control, cancer, and heritable disorders. Cell. 2000 Apr 21;103(4):295-309.
[2] Chen Y G, Wang Q, Lin S L, et al. Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Experimental biology and medicine, 2006, 231(5): 534-544.
[3] Harrison C A, Gray P C, Vale W W, et al. Antagonists of activin signaling: mechanisms and potential biological applications. Trends in Endocrinology & Metabolism, 2005, 16(2): 73-78.
[4] Ghorbani-Dalini S, Azarpira N, Sangtarash M H, et al. Optimization of activin-A: a breakthrough in differentiation of human induced pluripotent stem cell into definitive endoderm. 3 Biotech, 2020, 10(5): 215.
[5] Mennen R H, Oldenburger M M, Piersma A H. Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing. Reproductive Toxicology, 2022, 107: 44-59.
[6] Ries A, Schelch K, Falch D, et al. Activin A: an emerging target for improving cancer treatment?. Expert Opinion on Therapeutic Targets, 2020, 24(10): 985-996.
