產品詳情介紹
干細胞因子（Stem cell factor, SCF），也稱為KIT配體，是一種結合酪氨酸激酶受體（c-kit）的細胞因子。SCF也被稱為“c-kit配體”[1-2]。SCF是一種對造血干細胞和其他造血祖細胞的存活、增殖和分化很重要的生長因子。其作用之一是將紅細胞系列中最早的紅細胞前體BFU-E（突發(fā)形成單位紅細胞）細胞轉變?yōu)镃FU-E（集落形成單位紅細胞）[3]。重組SCF可以與G-CSF聯合使用，提高外周血中CD34+細胞的濃度，動員外周血祖細胞（PBPC），快速恢復癌癥患者的骨髓造血功能。在自體造血干細胞移植中，SCF的使用可以增加動員到外周血的造血干細胞數量，有助于收集足夠數量的干細胞以進行移植[4]。
[1] Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC, et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor[J]. Cell, 1990, 63(1):213-224.
[2] Williams DE, Lyman SD. Characterization of the gene-product of the Steel locus. Prog Growth Factor Res, 1991,3(4):235-242.
[3] Bazan JF. Genetic and structural homology of stem cell factor and macrophage colony-stimulating factor. Cell, 1991, 65(1):9-10.
[4] da Silva, M., Pimentel, P., Carvalhais, A. et al. Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection. Bone Marrow Transplant, 2004, 34, 683–691.
